ADAM J. HARRINGTON
- Harvard title(s): Postdoctoral Research Fellow
- McLean title(s): Postdoctoral Fellow, Integrative Neurobiology Laboratory
- Email: email@example.com
- Telephone: 617-855-4102
- Office Address: Mailman 313, Bay G
- B.S. in Biology - University of Louisiana Monroe
- Ph.D. in Molecular and Cellular Biology - University of Alabama
- Bio: Adam is interested in studying the molecular mechanisms underlying autism-spectrum disorders using the mouse model system. The Louisiana native earned his doctorate in the Caldwell lab at the University of Alabama, where he utilized the C. elegans model system to identify genetic modifiers of dopaminergic neuron degeneration and focused on the role of the lysosomal protein VPS41 as a potential therapeutic target for Parkinson's disease. At McLean Hospital, Adam works in the Integrated Neurobiology Laboratory with Dr. Christopher Cowan where he is studying the developmental requirement of the transcription factor MEF2 in brain development and autism-associated behaviors.
- Publications: PubMed Search Harrington AJ [AU]
- Harrington AJ, Yacoubian TA, Slone SR, Caldwell KA, Caldwell GA. (2012). Functional analysis of VPS41-mediated neuroprotection in C. elegans and mammalian models of Parkinson's disease. Journal of Neuroscience. 32(6):2142-2153.
- Harrington AJ, Knight AL, Caldwell GA, Caldwell KA. (2011). C. elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease. Methods. 53:220-225.
- Tucci ML, Harrington AJ, Caldwell GA, Caldwell KA. (2011). Modeling dopamine neuron degeneration in C. elegans. Methods in Molecular Biology. 793:129-148.
- Pivtoraiko VN, Harrington AJ, Luker AM, Caldwell GA, Caldwell KA, Roth KA, Shacka JJ. (2010). Bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. Journal of Neurochemistry. 114(4):1193-1204.
- Harrington AJ, Hamamichi S, Caldwell GA, Caldwell KA. (2010). C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease. Developmental Dynamics. 239 (5):1282-1295.
- Yacoubian TA, Slone SR, Harrington AJ, Hamamichi S, Schieltz JM, Caldwell KA, Caldwell GA, Standaert DG. (2010). Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease. Cell Death and Disease. 1. pii: e2.
- Ruan Q, Harrington AJ, Caldwell KA, Caldwell GA, Standaert DG. (2010). VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiology of Disease. 37(2):330-338.
- Berkowitz LA, Hamamichi S, Knight AL, Harrington AJ, Caldwell GA, Caldwell KA. (2008). Applications of C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes. Journal of Visualized Experiments. 18;(17) pii: 835. doi: 10.3791/835.