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BILL CARLEZON, PHD

• Harvard title(s): Associate Professor of Psychiatry and Neuroscience
• McLean title(s): Director, Behavioral Genetics Laboratory
• Email: carlezon@mclean.harvard.edu
• Telephone: (617) 855-2021
• Fax: (617) 855-2023
• Office Address: Behavioral Genetics Laboratory and Medicinal Discovery and Development Laboratory
• Degree(s): Bill Carlezon received a B.Sc. in Biology and Psychology from Bates College. After college, he worked for several years at Hoechst-Roussel Pharmaceuticals in the drug discovery laboratories and, for a short time, he helped to conduct Phase II-III clinical trials of an experimental treatment for Alzheimer's disease. He then received a Ph.D. in Psychology at Concordia University in Montreal, and trained as a postdoctoral associate in Molecular Biology at Yale University School of Medicine.
• Bio: Bill has received several awards for his research, including an Independent Investigator Award from the National Alliance for Research on Schizophrenia and Depression (NARSAD), the Presidential Early Career Award for Scientists and Engineers (PECASE) from George W. Bush, and the Jacob P. Waletzky Award for Innovative Research in Drug Addiction and Alcoholism from the Society for Neuroscience (SfN).
• Publications:
  • PubMed search for Carlezon WA [au]
  • Carlezon WA Jr, Thome J, Olson VG, Lane-Ladd SB, Brodkin ES, Hiroi N, Duman RS, Neve RL, Nestler EJ. (1998) Regulation of cocaine reward by CREB. Science 282: 2272-2275.
  • Kelz MB, Chen JS, Carlezon WA Jr, Whisler K, Gilden L, Steffen C, Zheng YJ, Marotti L, Self DW, Tkatch T, Baranauskas G, Surmeier DJ, Neve RL, Duman RS, Picciotto MR, Nestler EJ (1999) Expression of the transcription factor *FosB in the brain controls sensitivity to cocaine. Nature 401: 272-276.
  • Carlezon WA Jr, Haile CN, Coopersmith R, Hayashi Y, Malinow R, Neve RL, Nestler EJ (2000) Distinct sites of opiate reward and aversion within the midbrain identified by a herpes simplex virus vector expressing GluR1. Journal of Neuroscience 20: RC62, 1-5.
  • Carlezon WA Jr, Todtenkopf M, McPhie DL, Pimentel P, Pliakas AM, Stellar J, Trzcinska M (2001) Downregulation of GluR1 expression in the ventral tegmental area following repeated rewarding brain stimulation. Neuropsychopharmacology 25: 234-241.
  • Josselyn SA, Shi CJ, Carlezon WA Jr, Neve RL, Nestler EJ, Davis M. (2001) Long-term memory is facilitated by cAMP response-element binding protein overexpression in the amygdala. Journal of Neuroscience 21: 2404-2412.
  • Pliakas AM, Carlson R, Neve RL, Konradi C, Nestler EJ, Carlezon WA Jr (2001) Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element binding protein expression in nucleus accumbens. Journal of Neuroscience 21: 7397-7403.
  • Andersen SL, Arvanitogiannis A, Pliakas AM, LeBlanc C, Carlezon WA Jr (2002) Altered responsiveness to cocaine in rats exposed to methylphenidate during early development. Nature Neuroscience 5: 13-14.
  • Carlezon WA Jr, Pliakas AM, Parow AM, Detke MJ, Cohen BM, Renshaw PF (2002) Antidepressant-like effects of cytidine in the forced swim test in rats. Biological Psychiatry 51: 882-889.
  • Gilliss B, Malanga CJ, Pieper JO, Carlezon WA Jr (2002) Cocaine and SKF-82958 potentiate brain stimulation reward in Swiss-Webster mice. Psychopharmacology 163: 238-248.
  • Carlezon WA Jr (2003) Place conditioning to study drug reward and aversion. Methods in Molecular Medicine 84: 243-249.
  • Carlezon WA Jr, Wise RA (2003) Unmet expectations: the brain minds. Nature Medicine 9: 15-16.
  • Mague SD, Pliakas AM, Todtenkopf MS, Tomasiewicz HC, Zhang Y, Stevens WC Jr., Jones RM, Portoghese PS, Carlezon WA Jr (2003) Antidepressant-like effects of kappa opioid receptor antagonists in the forced swim test in rats. Journal of Pharmacology and Experimental Therapeutics 305: 323-330.
  • Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA Jr (2003) Dopamine-dependent increases in CREB phosphorylation during precipitated morphine withdrawal in primary cultures of rat striatum. Journal of Neurochemistry 87: 107-118.
  • Todtenkopf MS, Marcus JF, Portoghese PS, Carlezon WA Jr (2004) Effects of kappa opioid ligands on intracranial self-stimulation in rats. Psychopharmacology 172: 463-470.
  • Carlezon WA Jr, Konradi C (2004) Understanding the Neurobiological Consequences of Early Exposure to Psychotropic Drugs: Linking Behavior with Molecules. Neuropharmacology 47S1: 47-60.
  • Bonci A, Carlezon WA Jr (2005) Ion Channels and Intracellular Signaling Proteins as Potential Targets for Novel Therapeutics for Addictive and Depressive Disorders. Pharmacology and Therapeutics, in press.
  • Carlezon WA Jr, Duman RS, Nestler EJ (2005) The many faces of CREB. Trends in Neurosciences, in press.
  • Carlezon WA Jr, Mague SD, Parow AM, Stoll AL, Cohen BM, Renshaw PF (2005) Antidepressant-like effects of uridine and omega-3 fatty acids potentiated by coadministration in rats. Biological Psychiatry 57: 243-250.
  • Carlezon WA Jr, Rohan ML, Mague SD, Meloni EG, Cayetano K, Tomasiewicz HC, Rouse ED, Cohen BM, Renshaw PF (2005) Antidepressant-like Effects of Cranial Stimulation within a Low Energy Magnetic Field in Rats. Biological Psychiatry 57: 571-576.
  • Mague SD, Andersen SL, Carlezon WA Jr (2005) Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats. Biological Psychiatry 57: 120-125.
  • Carlezon WA Jr, Duman RS, Nestler EJ (2005) The many faces of CREB. Trends in Neurosciences 28: 436-445
  • Carlezon WA Jr, Beguin C, DiNieri J, Baumann MH, Richards M, Todtenkopf MS, Rothman RB, Ma Z, Lee DY-L, Cohen BM (2006) Depressive-like effects of the kappa-opioid receptor agonist Salvinorin A on behavior and neurochemistry in rats. Journal of Pharmacology and Experimental Therapeutics 314: 440-447
  • Chartoff EH, Mague SD, Barhight MF, Smith AM, Carlezon WA Jr (2006) Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. Journal of Neuroscience 26: 6450-6457
  • Meloni EG, Gerety LP, Knoll AT, Cohen BM, Carlezon WA Jr (2006) Behavioral and anatomical interactions between dopamine and corticotropin-releasing factor (CRF) in the rat. Journal of Neuroscience 26: 3855-3863