Cécile Béguin, PhD
- Harvard title(s): Assistant Professor of Psychiatry
- Email: cbeguin@mclean.harvard.edu
- Telephone: (617) 855-2080
- Fax: (617) 855-3479
- Office Address: Molecular Pharmacology Laboratory (MRC 322A)
- Degree(s): Dr. Béguin received an M.S. degree in Chemistry from CPE Lyon (France) and a Ph.D. in Organic Chemistry from the University of Houston. Under the supervision of Dr. Harold Kohn, she designed, synthesized, and evaluated peptidomimetics of harkoseride (lacosamide), a chiral agent with a unique pharmacological profile. Harkoseride has entered Phase III clinical trials for epilepsy and diabetic neuropathy.
- Bio: Her current research focuses on the synthesis and evaluation of molecules of medicinal interest for the care of patients with mood and psychotic disorders. Specifically, she is developing a range of ligands that have selectivity for the trace monoamine receptors, as well as molecules acting as full agonists, antagonists, and partial agonists at the kappa-opioid receptor.
- Publications:
- Béguin C, Potter DN, Di Nieri JA, Munro TA, Richards MR, Paine TA, Berry L, Zhao Z, Roth BL, Xu W, Liu-Chen L-Y, Carlezon WA Jr, Cohen BM. N-methylacetamide analogue of salvinorin A: a highly potent and selective kappa opioid receptor agonist with oral efficacy. J Pharmacol Exp Ther, accepted.
- Munro TA, Duncan KK, Xu W, Wang Y, Liu-Chen L-Y, Carlezon WA Jr, Cohen BM, Béguin C. Standard Protecting Groups Create Potent and Selective κ Opioids: Salvinorin B Alkoxymethyl Ethers. Bioorg Med Chem, accepted.
- Béguin C, Richards MR, Li J-G, Wang Y, Xu W, Liu-Chen L-Y, Carlezon WA Jr, Cohen BM. Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18). Bioorg Med Chem Lett 2006, 16:4679-4685.
- Carlezon WA Jr, Béguin C, Di Nieri JA, Baumann MH, Richards MR, Todtenkopf MS, Rothman RB, Ma Z, Lee DYW, Cohen BM. Depressive-like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats. J Pharmacol Exp Ther 2006, 316:440-447.
- Béguin C, Richards MR, Chen Y, Wang Y, Liu-Chen L-Y, Ma Z, Lee DYW, Carlezon WA Jr, Cohen BM. Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2). Bioorg. Med. Chem. Lett. 2005, 15:2761-2765.
- Béguin C, Le Tiran A, Stables JP, Voyksner RD, Kohn H. N-substituted amino acid N'-benzylamides: synthesis, anticonvulsant, and metabolic activities. Bioorg. Med. Chem. 2004, 12:3079-3096.
- Shen M, Béguin C, Golbraikh A, Stables JP, Kohn H, Tropsha A. Application of Predictive QSAR Models to Database Mining: Identification and Experimental Validation of Novel Anticonvulsant Compounds. J. Med. Chem. 2004, 47:2356-2364.
- Béguin C, Andurkar SV, Jin AY, Stables JP, Weaver DF, Kohn H. Functionalized Amido Ketones: New Anticonvulsant Agents. Bioorg. Med. Chem. 2003, 11:4275-4285.
- Andurkar SV, Béguin C, Stables JP, Kohn H. Synthesis and Structural Studies of Aza Analogues of Functionalized Amino Acids: New Anticonvulsant Agents. J. Med. Chem. 2001, 44:1475-1478.
