MARISA M. SILVERI, PHD
- Harvard title(s): Assistant Professor of Psychiatry, Harvard Medical School
- McLean title(s): Director, Neurodevelopmental Laboratory on Addictions and Mental Health
- Email: firstname.lastname@example.org
- Telephone: (617) 855-2920
- Fax: (617) 855-2770
- Office Address: Brain Imaging Center, McLean Hospital, 115 Mill St. Belmont, MA 02478
Over the past 15 years I have conducted preclinical and clinical research on the behavioral and neurobiological correlates of substance use and abuse, with a focus on adolescence. My preclinical work demonstrates that adolescence is a period of relative insensitivity to alcohol, which is extremely relevant given that alcohol use typically begins during this time, and that age of onset of use is a significant predictor of later abuse and dependence. I transitioned from preclinical to clinical research in order to utilize non-invasive magnetic resonance techniques in humans, permitting the investigation of healthy adolescent brain development as a means to understanding the neurobiological and neuropsychological consequences of substance abuse and the manifestation of dependence. I direct the Neurodevelopmental Laboratory on Addictions and Mental Health, within the Brain Imaging Center, which focuses on behavioral features of adolescent development, increased risk taking, poor decision-making, impulsivity and reduced frontal lobe function, which overlap with features observed in substance abuse and psychiatric illness. I have given talks and presented posters in this area both nationally and internationally over the past several years. I currently serve as PI on grants from the NIAAA examining the neurobiological consequences of binge alcohol consumption during "emerging" adulthood, and sex differences in hippocampal function and neurochemistry in alcohol dependence. I have received the Enoch Gordis Research Recognition Award and the 2011 Young Investigator Award from the Research Society on Alcoholism.
I have served as course instructor for psychology and behavioral neuroscience courses, and recently a graduate/medical student neuroimaging seminar. I supervise and mentor undergraduates, graduate students, research assistants, post docs and junior faculty. I also dedicate a significant amount of time to patient education and community outreach; locally, regionally and nationally, to audiences that include teachers, guidance and adjustment counselors, psychologists, nurses, parents and students. These presentations focus on neuroimaging research on the maturation of the adolescent brain and the consequences of early alcohol and drug use. Dissemination through community outreach has been a successful means of increasing public awareness about the vulnerability of the adolescent brain, as a prevention effort to discourage alcohol and drug use during adolescence, but also, to educate the public on the importance of the early identification of clinical and behavioral indicators of psychiatric illness in adolescents.
The remainder of my professional time is dedicated to McLean Hospital committee work, the Joint Committee on the Status of Women at HMS/HSDM, and serving as a reviewer for applications for the National Institute on Drug Abuse Clinical Loan Repayment Program, grant review for the National Institute on Alcohol Abuse and Alcoholism, and manuscripts as an ad hoc reviewer for peer-reviewed journals.