EDGAR (NED) A. BUTTNER, MD, PHD
- Harvard title(s): Instructor in Psychiatry
- McLean title(s): Assistant Research Neurologist and Director of the Pharmacogenomics Section of the Molecular Pharmacology Laboratory
- Email: nbuttner@gmail.com
- Telephone: (617) 855-2074
- Fax: (617) 876-5148
- Office Address: Service Building, Room 03, McLean Hospital, 115 Mill Street, Belmont, MA 02478
- Degree(s):
- 1993 M.D. Columbia University - Presbyterian Medical Center
- 1992 Ph.D. Columbia University - Presbyterian Medical Center, Physiology & Cellular Biophysics
- 1984 B.A. Williams College
- Residency:
- 1997 - 2001 HHMI Postdoctoral Research Fellowship for Physicians, Massachusetts Institute of Technology,
Department of Biology/HHMI (MIT)
- 1994 - 1997 Residency Training Program University of California, Los Angeles Medical Center Department of Neurology
- 1993 - 1994 Preliminary Year Internship, New York Hospital/Cornell University Medical Center, Department of Internal Medicine
- Fellowship:
- 2001-2003 Research Associate/Instructor, Structural and Molecular Neuroscience, McLean Hospital
- 2003-2007 Research Associate, Molecular and Cellular Biology, Harvard University
- Board Certifications(s):
- 1999 ABPN Board Certification (#47010)
- Clinical Interests: Ned conducts pharmacogenomic studies in Caenorhabditis elegans and knockout mice to understand the mechanisms of action of drugs used to treat neurological and psychiatric diseases. He also uses reverse genetic approaches to study neurological disease gene orthologs in C. elegans.
- Bio: Ned is an Instructor in Psychiatry at Harvard Medical School, and he is the Director of the Pharmacogenomics Section of the Molecular Pharmacology Laboratory at McLean Hospital.
- Curriculum vitæ: (PDF format)
- Publications:
- Karmacharya, R., Sliwoski, G.R., Lundy M.Y., Suckow, R.F., Cohen, B.M., Buttner, E.A. Clozapine Interaction with Phosphatidyl Inositol 3-Kinase (PI3K)/Insulin-Signaling Pathway in Caenorhabditis elegans. Neuropsychopharmacology 2009;34:1968-78.
- Buttner, E.A., Gil-Krzweska, A., Rajpurohit, A., Hunter, C. Progression from Mitotic Catastrophe to Cell Death Requires the Spindle Checkpoint in C. elegans. Developmental Biology 2007;305:397-410.
- Buttner, E.A., Bhattacharyya, S., Walsh, J., Benes, F.M. DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder. Schizophrenia Research 2007;93:33-41.
- Buttner, N. and Siegelbaum, S.A. Antagonistic modulation of a hyperpolarization-activated chloride current in Aplysia sensory neurons by SCPβ and FMRFamide. Journal of Neurophysiology 90 (2) (2003): 586-598.
- Leibeskind, D.S., Ostrzega, N., Wasterlain, C.G., and Buttner, E.A. Neurologic manifestations of disseminated infection with Mycobacterium abscessus. Neurology 56 (6) (2001): 810-813.
- Buttner, N., Geschwind, D.H., Jen, J., Perlman, S., Pulst, S.M., and Baloh, R.W. Oculomotor phenotypes in the SCA syndromes. Archives of Neurology 55 (10) (1998): 1353-1357.
- Volterra, A., Buttner, N., and Siegelbaum, S.A. Direct opening of S-type K+ channels of Aplysia sensory neurons by 12-lipoxygenase metabolites. Adv. Prostaglandin Thromboxane Leukotriene Res. 21B (1991): 727-730.
- Buttner, N., Siegelbaum, S.A., and Volterra, A. Direct modulation of Aplysia S-K+ channels by a 12-lipoxygenase metabolite of arachidonic acid. Nature 342 (1989): 553-555.
- Siegelbaum, S.A., Volterra, A., and Buttner, N. Antagonistic modulation of the S-K+ channel of Aplysia sensory neurons by lipoxygenase metabolites of arachdonic acid and cAMP. Biology of Cellular Transducing Signals. J. Vanderhoek, ed. Plenum, New York (1989): 371-379.
- Karmacharya, R., Demarco, S., Ortiz, A., Lundy, M.Y., Cohen B.M., Buttner E.A. Trace Amine Pathways Mediate Behavioral Effects of Antipsychotics in Caenorhabditis elegans. Journal of Neuroscience Research, 2009, submitted.
- Gil-Krzewska, A.J., Farber, E., Buttner, E.A., Hunter, C.P. Regulators of the Actin Cytoskeleton Mediate Lethality in a Caenorhabditis elegans dhc-1 mutant. Molecular Biology of the Cell, 2010 Aug 1;21(15):2707-20
- Buttner, E.A., Price, B.H. Depression: Neurology, Psychiatry and Neuroscience. In preparation.
- Sliwoski, G.R., Buttner, E.A. The Nematode Caenorhabditis elegans is a Model System for the Study of Psychiatric Disease Genes. In preparation.
