NICHOLAS T. LANGE, SCD
- McLean title(s): Associate Professor of Psychiatry and Biostatistics & Director, Neurostatistics Laboratory, Harvard Medical School / Harvard School of Public Health
- Email: nlange@hms.harvard.edu
- Telephone: (617) 855-2139
- Fax: (617) 855-2040
- Office Address: Neurostatistics Laboratory, MRC 314, 115 Mill Street. Belmont, MA 02478
- Degree(s): Nick received a B.S. in Mathematics from Northeastern University, a M.S. in Computer Science from the University of Massachusetts Amherst, and an Sc.D. in Biostatistics from Harvard University in 1986.
- Bio: Dr. Lange has won several awards for his academic research including the Robert Reed Prize in Biostatistics from Harvard University, an invited paper read before the Royal Statistical Society, London, and Who's Who in America. His current research interests include the development of novel biostatistical methodology for pediatric brain development by in vivo MRI, childhood autism, diffusion tensor imaging and immunohistochemistry.
- Publications:
- Lange N and Ryan L. Assessing normality in random effects models, Annals of Statistics 1989;17:624-642.
- Lange N. Statistical approaches to human brain mapping by functional magnetic resonance imaging. Stat Med 1996;15:389-428.
- Lange N, Zeger SL. Non-linear Fourier time series analysis for human brain mapping by functional magnetic resonance imaging (with Discussion). J Royal Stat Soc, Appl Stat 1997;46:1-29.
- Lange N, Giedd JN, Castellanos FX, Vaituzis AC, Rapoport JL. Variability in human brain structure size: ages 4 to 20. Psych Res Neurim. 1997;74:1-12.
- Kennedy DN, Lange N, Makris N, Bates J, Meyer J, Caviness VS Jr. Gyri of the human neocortex: An MRI-based analysis of volume and variance. Cerebral Cortex 1998;8(4):372-384.
- Caviness VS Jr., Lange NT, Makris N, Herbert MR, Kennedy DK. MRI-based brain volumetrics: emergence of a developmental brain science. Brain and Development 1999;21:289-295.
- Lange N, Strother SC, Anderson JR, Nielsen FA, Holmes AP, Kolenda T, Savoy R, Hansen LK. Plurality and resemblance in fMRI data analysis. NeuroImage 1999;10:282-303.
- Benes FB and Lange N. Two-dimensional versus three-dimensional cell counting: A practical perspective. Trends Neurosci 2001; 24:11-17.
- Young D, Ma J, Cherkerzian S, Froimowitz MP, Ennulat DJ, Cohen BM, Evans M, Lange N. Automated identification of Fos expression. Biostatistics 2001; 2:351-364.
- Sperling R, Greve D, Dale A, Killiany R, Holmes J, Rosas HD, Cocchiarella A, Firth P, Rosen B, Lake S, Lange N, Routledge C, Albert M. Functional MRI detection of pharmacologically induced memory impairment. Proc. Nat. Acad. Sci. USA 2002; 99:455-460.
- Lange N, Sperling R, Albert M, Heckers S. Two macroscopic and microscopic brain imaging studies of human hippocampus in early Alzheimer's disease and schizophrenia research. Stat. Med. 2004; 23(2):327-350.
- Lange N. What can modern statistics offer imaging neuroscience? Stat. Meth. Med. Res. 2003; 12(5):447-469.
- Berretta S, Lange N, Bhattacharyya S, Sebro R, Garces J and Benes FM. Long term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneurons. Hippocampus 2004; 14:876-894.
- Wager CG, Coull BA, Lange N. Modeling spatial intensity for replicated inhomogeneous point patterns in brain imaging. J. Roy. Stat. Soc., Ser B 2004; 66:429-446.
- Harezlak J, Ryan LM, Giedd JN, Lange N. Individual and population penalized regression splines for accelerated longitudinal designs. Accepted for publication, Biometrics.
