SANGMI CHUNG, PHD
- McLean title(s): Postdoctoral Fellow
- Email: schung@mclean.harvard.edu
- Telephone: (617) 855-2020
- Office Address: Molecular Neurobiology Laboratory
- Degree(s): B.Sc. 1993, Ph.D. 1998
- Clinical Interests: Stem cell maintenance and differentiation into specific lineages.
- Bio: Sangmi Chung received her B.Sc. in Microbiology from Seoul National University. She then moved to Cornell University Graduate School of Medical Sciences to pursue a graduate career in Neuroscience where she earned her Ph.D. She joined Dr. Kim's laboratory in 1999 as Postdoctoral fellow.
- Publications:
- Chung, S., L. Jiang, S. Cheng, and H.M. Furneaux, Purification and properties of HuD, a neuronal RNA binding protein. J. Biol. Chem., 1996. 271: p. 11518-11524.
- Chung, S., N. Perrone-Bizzozero, D.T. Kohn, and H. Furneaux, The Elav-like proteins bind to a conserved regulatory element in the 3'UTR of GAP-43 mRNA. J.Biol.Chem.,1997. 272:p.6593-6598.
- Ma, W.-J., S. Chung, and H.M. Furneaux, The Elav-like RNA binding proteins promote an interaction between AU rich elements and the poly A tail of mRNA. Nucleic Acids Research, 1997. 25: p. 3564-3569.
- Levy, N., S.Chung, H.M.Furneaux, and A. Levy, Hypoxic stabilization of VEGF mRNA by the RNA-binding protein HuR, J. Biol. Chem., 1998. 273: p.6417-6423.
- Aranda-abreu,G., L.Behar, S.Chung, H.M.Furneaux, and I. Ginzburg, HuD regulates Tau expression and Neurite outgrowth in PC12 cells, J. Neuroscience, 1999. 19(16): p. 6907-17.
- Isacson, O., Costantini, L.C., Schumacher, J.M., Cicchetti, F., Chung, S. and Kim, K.-S. Cell implantation therapies for Parkinson's diesase using neural stem, transgenic or xenogenic donor cells. Parkinsonism and Related Disorders, 2001. 7: p. 205-212.
- Chung, S., Andersson, T., Sonntag, K.-C., Björklund, L., Isacson, O. and Kim, K.-S. Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines. Stem Cells, 2002. 20(2): p.139-45.
- Björklund, L., Sánchez-Pernaute, R., Chung, S., Andersson, T., Chen, I., McNaught, K., Brownell, A., Jenkins, B., Wahlestedt, C., Kim, K.-S. and Isacson, O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc. Natl. Acad. Sci. USA, 2002. 99(4): p. 2344-9.
- Chung, S., Sonntag, K.-C. , Andersson, T., Björklund, L. M., Park , J.-J., Kim, D.-W., Kang, U., Isacson, O. and Kim, K.-S. Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. Eur. J. Neurosci., 2002. 16(10): p.1829-38.
- Kim, K.-S., Kim, C.-H., Hwang, D.-Y., Seo, H., Chung, S., Hong, S. J., Lim, J.-K., Anderson, T., and Isacson, O. Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner . J. Neurochem., 2003. 85(3): p. 622-34.
- Chung, S., Hwang, M., Kim, D.W., Hedlund, E., Hwang, D.-Y., Isacson, O. and Kim, K.-S. Exogenous expression of the homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into A9-like DA neurons., MCN, 2005. 28(2):241-52.