CLINICAL UNIT BASED RESEARCH

Testing of Medical Devices for Use in Psychiatric Disorders

The DBRP has a long-standing interest, and special expertise, in the evaluation of medical devices for the diagnosis, assessment and treatment of psychiatric disorders. We were one of the first groups to conduct research on the effect of light for treating Seasonal Affective Disorder, and have pioneered the use of Actigraphy for neuropsychiatric assessments.

Recently Funded and Completed Projects

Kodak, Inc.

Donation of new technology (4 issued patents, 18 pending patents) for assessment of ADHD, with funding to develop and commercialize this technology.

Ambulatory Monitoring Inc.

NIMH R44 MH058038 (SBIR to Tom Kazlausky, Ambulatory Monitoring Inc.)
"Reducing hyperactivity with a feedback actigraph"

BioBehavioral Diagnostic Corporation
1. "Multi-Center Pilot Study of the M-MAT/ADHD System to Monitor Response of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder to Either a Given Dose or Type Medication"
2. "Objective Measurement of ADHD in Adolescents
3. "Adult Normative Performance on the McLean-Motion and Attention Test"

Ongoing Studies

The Litebook Company Ltd.

"A Multi-center, Randomized Controlled Trial of Negative Ion Generation versus Light-Emitting Diode Phototherapy for Seasonal Affective Disorder (SAD)"

CNS Response Inc.

A Multicenter, Randomized, Blinded, Controlled, Parallel Group Trial to Demonstrate the Efficacy of rEEG-Guided Pharmacotherapy of Subjects with Depression Treatment Failure"

We are happy to work with companies, small and large, to plan and conduct studies to evaluate new devices. We have conducted trials in children, adolescents and adults with depression, ADHD, PTSD, bipolar disorder, borderline personality disorder, and anxiety disorders. We also have considerable experience with functional MRI neuroimaging (particularly voxel-based relaxometry and functional connectivity analysis), which could be used to visually demonstrate effects of new technologies on brain function.

Please contact Dr. Teicher (martin_teicher@hms.harvard.edu) with questions.