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CLINICAL UNIT BASED RESEARCH

Nursing Research

Carol Glod

Carol Glod, R.N., Ph.D.

Investigators in the Nursing Research program of Dr. Carol Glod, R.N., Ph.D., have focused on Developmental Studies, and are one of the first groups in the country to investigate bupropion (Wellbutrin) in the treatment of adolescent major depression.

In an initial study, we found that bupropion appears to be a safe and effective treatment for adolescent depression (Glod et al, Journal of Child and Adolescent Psychiatric Nursing Vol 16, (3), 2003). We have taken these results further to compare the effectiveness of bupropion to citalopram (Celexa) in a randomized placebo-controlled trial in depressed adolescents ages 12 to 19. To date there are no published studies comparing the newer antidepressants.

The other major area of research has been in collaboration with the cognitive neuroimaging center and Dr. Deborah Yurgelun-Todd and colleagues. Using functional Magnetic Resonance Imaging (fMRI), we have compared depressed and healthy adolescents and depressed adolescents before and after antidepressant treatment. Those adolescents with depression, prior to medication treatment, demonstrated significant parietal and cerebellar activation, while matched healthy controls demonstrated dorsolateral prefrontal cortex activation and cingulate activation (Glod et al., New York Academy of Sciences, 2003). After antidepressant treatment, depressed adolescents revealed significant activation in the right prefrontal cortex, right prefrontal gyrus, and right amygdala, depending on which condition they were viewing during the fMRI.

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