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CLINICAL UNIT BASED RESEARCH

Schizophrenia and Bipolar Disorder Program

MRS
Figure 1. Single-voxel TE-averaged spectra from the anterior cingulate cortex in a control subject (left) and bipolar disorder patient (right).
NAA - n-acetylaspartate; Glu - glutamate; Cre - creatine; Cho - choline; mI - myoinositol
(click image to return)

fMRI
Figure 2. A set of brain areas that are active at rest and share a similar timecourse of activity is shown.  The top row represents the average "resting state network" from a group of 15 healthy controls, the middle row 14 schizophrenia patients, and the bottom row 17 bipolar disorder patients.  It is clear that there are broad similarities in the brain areas in this network across conditions, but there are also subtle differences, which we are currently investigating.
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fMRI
Figure 3 shows significant differences in default mode network spatial extent between normal control and bipolar disorder subjects in whole brain analysis mapped onto parasagittal, coronal, and axial slices from a single subjects' structural image in Talairach space; A) Normal control > Bipolar disorder; B) Bipolar disorder > Normal control. In each panel, average z-scores from a highlighted cluster are shown for normal control (gray) and bipolar disorder (black) groups. p=0.001, uncorrected; spatial extent > 25 voxels.
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