MAILMAN RESEARCH CENTER
Formerly known as the Biological Research Laboratory, the Mailman Research Center (MRC) opened in 1946 and has undergone numerous expansions as the hospital's research program has grown, including the addition of a new wing in 1959, two new floors in 1977 and an $8 million east wing expansion in 1998 that brought its floor space to nearly one and a half acres, almost double its former laboratory capacity.
The MRC's research laboratories have grown from ten departments in 1997 to 22 departments in 2004, and are home to one of the foremost neuroscience programs in the world.
- Behavioral Genetics Laboratory
William Carlezon, Ph.D., Director
Linking drug-induced changes in gene expression with specific changes in complex motivated behaviors.
- Bio-Organic and Natural Products Research Laboratory
David Yue-Wei Lee, Ph.D., Director
Investigating Chinese herbal remedies used in the treatment of alcohol and drug abuse.
- Cellular Neurobiology Laboratory
Vadim Bolshakov, Ph.D., Director
Investigating the molecular mechanism of synaptic transmission.
- Laboratory of Developmental Neuropharmacology
Susan Andersen, Ph.D., Director
Investigating how such factors as sex, stress, and exogenous agents affect child and adolescent development.
- Harvard Brain Tissue Resource Center
Francine Benes, M.D., Ph.D., Director
A centralized resource for the collection and distribution of human brain specimens for brain research.
- Laboratory for Computational Neuroscience
Peter Siekmeier, M.D., Director
- Laboratory for Translational Neuroscience
Sabina Berretta, M.D., Director
Investigating the pathophysiological mechanisms of cellular and extracellular matrix abnormalities in schizophrenia and bipolar disorder
- Laboratory of Genetic Neuropharmacology
Uwe Rudolph, M.D., Director
Investigating the physiological and pharmacological functions of neurotransmitter receptor subtypes with relevance to psychiatric disorders.
- Molecular and Developmental Neurobiology Laboratory
Dona Lee Wong, Ph.D., Director
Studying how neural gene expression, rather than abnormalities in the genes themselves, may underly the pathophysiology of psychiatric illness.
- Molecular Neurobiology Laboratory
Kwang-Soo Kim, Ph.D., Director
Studying the mechanisms underlying neural circuits and the causes of associated brain diseases.
- Molecular Pharmacology Laboratory
Bruce M. Cohen, M.D, Ph.D., Director
Researching brain activation in response to monoaminergic drugs, changes to neuronal responsiveness following neurotransmission manipulation, and brain choline uptake and metabolism.
- Neuropharmacology Laboratory
Ross J. Baldessarini, M.D., Director
Conducting neurochemical, physiological and histochemical studies of the effects of known and novel drugs on central monoaminergic neurotransmission systems.
- Center for Neuroregeneration Research / Neuroregeneration Laboratories
Ole Isacson, Dr. Med. Sc., Director
Exploring the regenerative properties of stem cells and working towards a new understanding of neurodegenerative diseases.
- Neurostatistics Laboratory
Nicholas Lange, Sc.D., Director
Conducting studies using functional and anatomical magnetic resonance imaging, magnetic resonance spectroscopy and brightfield microscopy.
- Pre-Clinical Pharmacology Laboratory
Jack Bergman, Ph.D., Director
- Program for Structural and Molecular Neuroscience
Francine M. Benes, M.D., Ph.D., Director
Focused on defining how neural circuitry is altered in corticolimbic regions of schizophrenic and manic depressive brains.
- Psychiatric Neuroscience Laboratory
Frank Tarazi, Ph.D., Director
- Laboratory of Psychiatric and Molecular Neuroscience
Joseph Coyle, M.D., Director
Characterizing the mechanisms of glutamatergic neurotransmission and how pathologic dysruption of these processes may lead to selective neuronal degeneration.
- Psychology Research Laboratory
Deborah L. Levy, Ph.D., Director
Clarifying the genetic contributions to schizophrenia and bipolar disorder.
- Visual Psychophysiology Laboratory
Yue Chen, Ph.D., Director
Studying visual, visual cognitive and visuomotor processes to increase our understanding of core dysfunctions and underlying brain mechanisms in major psychiatric disorders.