MAILMAN RESEARCH CENTER
Laboratory for Translational Neuroscience
Glial cells expressing condroitin sulfate proteoglycans (CSPGs) were found to be markedly increased in layer II of the entorhinal cortex of subjects with schizophrenia (compare left upper and lower panels). Examples of such cells are shown in the two right lower panels. In the same subjects, CSPG-positive peri neuronal nets were decreased in layers II and III. Examples of perineuronal nets are shown in the two upper right panels and can be seen in the control subject in the upper left panel. These pericellular extracellular matrix condensations are known to be predominantly associated with neurons expressing parvalbumin and to regulate key neuronal functions during development and adulthood.
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