Alcohol and Drug Abuse Research Center
Center for Depression, Anxiety and Stress Research
McLean Imaging Center
Clinical Unit Based Research
Mailman Research Center
Shervert H. Frazier Research Institute
Clinical Trials
Inventions for License
Research News
Administration

MAILMAN RESEARCH CENTER

Molecular Pharmacology Laboratory

Molecular Pharmacology Laboratory Staff

The Molecular Pharmacology Laboratory Staff
(click to enlarge)

The investigators in the Molecular Pharmacology Laboratory study the mechanisms of action of currently available medications for Bipolar Disorders and Schizophrenia and work to identify new targets and new compounds to treat these and other neuropsychiatric disorders, including mood, anxiety, and psychotic disorders and dementias. Particular areas of recent or current research include:

Glial Glutamatergic Transmission

Hypothesis: Dysregulating glial glutamatergic transmission can induce anhedonia or dysphoria, prominent symptoms of depression.
(click to enlarge)

Nucleus Accumbens

Dynorphinergic cells are activated by clozapine
(click to enlarge)

Salvinorin Analogues

Synthesis of Salvinorin Analogues Modified at the C-2 Position
(click to enlarge)

Time-course study

Time-course study of larval arrest (wt N2 strain) in the presence of clozapine.
(click to enlarge)

Core Personnel and Associated Faculty

Representative Publications

Our work is supported by NIH grants, NARSAD and other foundation awards, industrial contracts, and private gifts.

04.2010