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Neurostatistics Laboratory

The Neurostatistics Laboratory The Neurostatistics Laboratory Staff

The Neurostatistics Laboratory Staff
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The Neurostatistics Laboratory (NSL) focuses on biostatistical methodology and its applications to in vivo and postmortem brain imaging of humans and animals. Our research interests include the following areas: functional and anatomical magnetic resonance imaging (MRI), diffusion tensor imaging and tractography (DT-MRI) and brightfield and immuno-fluorescence microscopy for brain tissue analysis of gene expression and interacting levels of a variety of neurotransmitters across brain structures. Our statistical methodologies include: 2D and 3D marked spatial point processes, longitudinal data analysis, spatio-temporal time series, Markov chain Monte Carlo (MCMC), semi-parametric regression, cluster analysis, and discriminant analysis.

NSL's present neuroscience projects include the development and application of statistical methods in MRI modalities for the study of healthy human brain development over the lifespan, child and adult schizophrenia, bipolar disorder, and childhood autism. We work closely with other scientists at McLean and worldwide in these research areas as peer collaborators, as well as conduct independent methodological research in neuroimaging biostatistics. The NSL houses a brightfield and immuno-fluorescence microscope with motion-programmable stage, and a host of computational hardware as well as a collection of biostatistical and image analysis software.

The lab is currently engaged in collaborations with several other laboratories at McLean Hospital, including Dr. Sabina Berretta's Laboratory for Translational Neuroscience and Dr. Bruce Cohen's Molecular Pharmacology Laboratory. Additional collaborations include the National Institutes of Health's MRI study of normal pediatric brain development, the National Institutes of Health's Collaborative Program of Excellence in Autism (CPEA) and National Institute of Mental Health’s Studies to Advance Autism Treatment (STAART) Network, Autism Speaks, and the Commonwealth Scientific and Industrial Research Organization (CSIRO), Australia.

The Neurostatistics Laboratory

Fig 1: Diffusion tensor imaging of the human brain, comparing a current method of analysis with a new method developed in the Neurostatistics Laboratory
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The Neurostatistics Laboratory

Fig. 2: Longitudinal parametric and smooth regression models for total cerebral human growth for young men and women
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The Neurostatistics Laboratory

Fig. 3: Automatic segmentation of digital images of Fos expression in rat brain for the identification, counting and spatial pattern detection of Fos-positive nuclei
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Research Support

Selected Publications