MAILMAN RESEARCH CENTER

Psychiatric Neuroscience Laboratory

The newly established Psychiatric Neuroscience Laboratory conducted several experimental studies aimed at better understanding of the neurobiology and pathophysiology of neurpsychiatric disorders and their improved treatment. This has been accomplished through close collaborations with colleagues in Neuropharmacology Laboratory and others in Mailman Research Center, as well as with external collaborators from other academic institutions and pharmaceutical companies in the USA and worldwide.

Our ongoing studies include:

Effects of antipsychotic drugs on dopamine receptors and their genes in developing rat brain
Long-term Effects of multiple doses of risperidone on DA receptors in juvenile animals
Effects of antipsychotics on reelin and GAD₆₇ expression in developing animals
Effects of antidepressant drugs on DA, 5-HT and Glu receptors in developing rat brain
Effects of novel antipsychotic drug asenapine on DA, 5-HT and Glu receptors in adult rat brain
Effects of CTDP-31,446 and its active metabolite CTDP-32,129 on monoamine transporters
Regulation of neurotransmitter receptors in dopamine D₄-knock out mice
Molecular effects and abuse of dopaminergic drugs in non-human primates
Behavioral effects of stimulants in juvenile vs. adult animals
Effects of norepinephrine reuptake blockers on behavioral hyperactivity in juvenile rats
Effects of dopamine D₄ antagonists on working memory
Effects of stimulants on sustained attention

Personnel

Frank I. Tarazi, PhD, MSc - Director
Rita Burke, AB
Christopher Grady, AB
Nora S. Kula, MS
Carla Massari, AB
Taylor Moran-Gates, AB
Young-Shik Park, PhD
Ross J Baldessarini, MD - Senior Collaborator

Collaborators: Marta Antonelli, PhD (U. of Buenos Aires); John Babich, PhD (Molecular Insights Pharmaceuticals); Ronald Baldwin, PhD (Vanderbilt U); Jack Bergman, PhD (ADARC); Eugen Davids, MD (U Essen); Lu Gan, MD (Tufts U); Lisa Gold, PhD (Pfizer, Inc); John Hennen, PhD (McLean); Brian Henry, PhD (Organon Laboratories); Dong-Youn Hwang (MRC); Kwang-Soo Kim, PhD (MRC); Leonard Meltzer, PhD (Pfizer, Inc); John Neumeyer, PhD (ADARC); Gahan Pandina, PhD (Janssen Pharmaceutica); Carol Paronis, PhD (ADARC); Marcello Rubenstein, PhD (U. of Buenos Aires); Mo Shadid, PhD (Organon Laboratories); Miles Smith, PhD (Molecular Insights Pharmaceuticals); Gilles Tamagnan, PhD (Yale U); Daniel Tarsy, MD (BIDH); Evangelia M. Tsapakis, MD (U London); John Waddington, PhD, DSc (Dublin College of Surgeons), Kehong Zhang, MD, PhD (MRC).